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➡️However, when combined with HCO-60 (a polyoxyethylene castor oil derivative) or Gelucire® 44/14 (long-chain fatty acid esters of glycerol and polyethylene glycol), it significantly increased mannitol permeability by 11.7-fold and 17.1-fold, respectively, while reducing transepithelial electrical resistance by over 80%, indicating tight junction opening
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