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Alterations in the expression or function of insulin-related genes, including INSR (insulin receptor), IRS1 (insulin receptor substrate 1), and AKT1 (AKT serine/threonine kinase 1), profoundly influence insulin sensitivity, glucose uptake, and the regulation of adipose tissue lipolysis [59]
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Yes — one Phase 2 trial is recruiting, and no results have been posted
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