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Peripheral peptide hormones are released postprandially and travel in the circulation to bind to their receptors in the homeostatic regulatory centers in the CNS, notably the arcuate nucleus (ARC) of the hypothalamus and the dorsal vagal complex (DVC) in the brainstem medulla
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The most studied angiogenic pathway stems from a 2017 study by Hsieh and colleagues, which combined a rat hind-limb model with cultured human vascular endothelial cells
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